Therapeutic potential of polyphenols in managing thalassemia: A comprehensive review
نویسندگان
1 Tabriz University of Medical Sciences , Tabriz , Iran
2 1Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran
3 Department of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran
4 Department of Medical Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan-Iran
5 Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
6 Department of Medical Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan-Iran
7 Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences,Mashhad, Iran
8 School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran
9 Department of Medical Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan-Iran
10 Department of Molecular Biology and Genetics, Canakkale Onsekiz Mart University, Canakkale 17100, Turkey
doi
10.22038/ajp.2025.26013چکیده
Objective: This study aims to review the potential effects of polyphenols on iron overload and inflammation in patients with β-thalassemia.Materials and Methods: A literature search in electronic databases was carried out to identify studies exploring the therapeutic effects of flavonoids in thalassemia.Results: Patients with thalassemia suffer from excess iron in their bodies. In these patients, splenectomy is usually performed as an effective method to reduce the iron load and the need for blood transfusion. However, since the removal of the spleen in these patients to reduce the excess iron load is faced with serious side effects, it has been suggested to harness iron-chelators. Dietary polyphenols and polyphenol-rich products such as quercetin, curcumin, and silymarin prevent iron overload by reducing the serum levels of iron and ferritin. Polyphenols also reduce inflammation and oxidative stress by reducing tumor necrosis factor-α, C-reactive protein and malondialdehyde, and increasing total antioxidant capacity.Conclusion: The iron-chelating capacity of polyphenols and flavonoids which may have fewer side effects in patients with thalassemia, has garnered significant attention and holds a promise for therapeutic purposes.
