فهرست نشریات علمی دسترسی آزاد ایران

Background: Vitamin D receptor (VDR) gene polymorphisms cause functional differences in immunomodulatory action of vitamin D. An association between VDR gene BSMI polymorphisms and systemic lupus erythematosus (SLE) has been documented. Objective: To compare the VDR gene BSMI polymorphisms in patients with SLE and healthy controls. Methods: This was a case-control study conducted in the city of Mashhad (Iran). Sixty patients with lupus from two outpatient rheumatology clinics and 45 non-relative healthy controls of the same sex were selected using the census procedure. VDR gene typing was performed based on polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). The results were analyzed using chi square test while a p<0.05 was considered as significant. Findings: The distribution of VDR genotyping of BSMI polymorphisms in patients with SLE were 23.3% for BB, 60% for Bb and 16.7% for bb. Similarly, the values found for healthy group were 33.3%, 46.7%, and 20% for BB, Bb, and bb, respectively. There was no statistically significant difference between two groups. Conclusion: No significant difference in relative frequency of VDR gene BSMI polymorphisms in SLE patients and healthy individuals was established.