فهرست نشریات علمی دسترسی آزاد ایران

Hydroxyapatite (HA) scaffolds are highly applicable in biological engineering, including medical implants and tissue engineering. On the other hand, because of the effect of uniform pressure in all directions, the cold isostatic press (CIP) is known as a suitable production method. In this essay, the natural hydroxyapatite powder is taken from natural bovine bone by thermal decomposition method and then by mixing the powder with salt as space holder, the scaffold is produced by CIP. The effect of the CIP pressure and the percentage of mixing of the space holder with the hydroxyapatite powder is investigated experimentally on the total porosity, compressive strength and biodegradability of the final product. The results showed that in 60% of the mixing space holder, increasing CIP pressure from 500 to 1000 increases compressive strength which is because of higher density of HA, but after that it decreases. Also, in 70% and 80% mixing percentage of space holder, from 500 to 1500 bar, the compressive strength decreases which is because of joining the space holder particles together and formation of very big cavities and the higher porosity. The mixing percentage of space holder and CIP pressure has a direct effect on biodegradability. By increasing CIP pressure from 500 to 1000 bar, biodegradability decreases, that is because of higher density of HA, but after that from 1000 to 1500 bar, the biodegradability increase, which is because of joining the space holder particles together and formation of large cavities.