Non-reactive pupils as early sign of Miller Fisher syndrome

نویسندگان

1 Department of Neurology, Cruces University Hospital, Barakaldo, Basque Country, Spain

2 Department of Neurology, Cruces University Hospital, Barakaldo, Basque Country, Spain

3 Department of Neurology, Cruces University Hospital, Barakaldo, Basque Country, Spain

4 Department of Neurology, Cruces University Hospital, Barakaldo, Basque Country, Spain

doi
10.18502/cjn.v19i3.5430
چکیده

Although the most characteristic symptoms of Miller Fisher syndrome (MFS) are ophthalmoplegia, areflexia, and ataxia, in 1956, Dr. Miller Fisher already described pupillary involvement in some patients. From that moment on, several articles have reported non-reactive dilated or tonic pupils in patients with MFS.1 We report two patients who debuted withsymptoms of dizziness and malaise (Video 1). On examination, the first patient had non-reactive mydriatic pupils and slight limitation for supraversion. The second patient had nonreactive dilated pupils with weak deep tendonreflexes. The rest of the examination was completely normal in both cases. In the next few days, patients developed ataxia, areflexia, and ophtalmoplegia. Both patients were diagnosed with MFS. We initiated early treatment withintravenous immunoglobulin for five days, with both patients recovering fully in less than a month.