Current Trends in Antibiotic Resistance Patterns of Pathogens in Urinary Tract Infections in Children in Karaganda, Kazakhstan
نویسندگان
1 Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana, Kazakhstan
2 Department of Zoology, Karaganda Buketov University, Karaganda, Kazakhstan
3 Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana, Kazakhstan
4 Department of Biology, M. Kozybayev North-Kazakhstan State University, Petropavlovsk, Kazakhstan
5 Department of Internal Diseases, Astana Medical University, Astana, Kazakhstan
6 Department of Anatomy, Physiology and Life Safety, Novosibirsk State Pedagogical University, Novosibirsk, Russian
7 Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana, Kazakhstan
8 Higher School of Natural Science, Pavlodar State Pedagogical University, Pavlodar, Kazakhstan
9 Department of Normal Physiology, Astana Medical University, Astana, Kazakhstan
doi
10.30476/ijms.2025.105826.3980چکیده
Background: Urinary tract infections (UTIs) are common in children and result in frequent hospitalization, creating a social and economic burden for parents and the healthcare system. This study analyzes the patterns of antibiotic resistance of dominant uropathogens and assesses the impact of patient age and sex on these patterns.Methods: This retrospective cohort study was conducted in Karaganda, Kazakhstan, between 2017 and 2022. Antibiotic resistance was assessed in two age groups: 0-12 months (Group I) and 13-60 months (Group II). Standard microbiological methods were used to identify UTI pathogens, and antibiotic resistance patterns were determined using the Kirby-Bauer disk diffusion method.Results: Among the 519 isolates (68.1%) from 762 children, the most common pathogens were Escherichia coli (170, 32.7%), Enterococcus faecalis (80, 15.4%), and Staphylococcus epidermidiss (46, 8.9%) in both age groups. Antimicrobial resistance in common pathogens in Groups I and II was high for amoxicillin (33 isolates, 76.7% and 45 isolates, 73.8%) and erythromycin (14 isolates, 73.7% and five isolates, 55.5%). Imipenem (31 isolates, 94%), amikacin (45 isolates, 90%), and meropenem (47 isolates, 87%) were effective against E. coli, whereas ceftriaxone (31 isolates, 97%) was more active against Gram-positive cocci. 157 (34%) uropatogens were resistant to multiple drugs, increasing with age: 72 (28%) (Group I) and 85 (43%) (Group II).Conclusion: The study demonstrated a progressive increase in the prevalence of multidrug-resistant uropathogens with age in the pediatric population. Periodic monitoring of uropathogens helps track the growth of multidrug-resistant strains.
