Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer
نویسندگان
1 Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2 Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3 Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
doi
چکیده
Colon microbiota, as a complex and diverse population, has been shown to be either pro- or anti-tumorigenic, depending on itscontent. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which prooranti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance inmicrobiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggestingthe contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells.
