فهرست نشریات علمی دسترسی آزاد ایران

Cancer is a leading cause of death globally, and poses a major challenge to public health systems everyplace. The tumorigenesis is essentially initiated by the deregulation of fundamental intracellular signaling pathways which control important cell processes such as proliferation, survival and differentiation. Aberrations in these pathways have been shown for decades to underlie many of the hallmark capabilities of cancer cells such as unlimited replicative potential. Targeting oncogenic signaling has therefore become a major therapeutic strategy. We provide a review of five signaling networks that are often deregulated in cancer: PI3K/AKT/mTOR, NF-kappaB, Wnt/beta-catenin, Notch and Hippo/YAP-TAZ signaling and provide a unified analysis of this group of networks. We review here current knowledge of their individual and cooperative roles in tumor pathogenesis, and discuss implications for developing specific anticancer therapies.