Protective effect of Mumiju against acetic acid-induced ulcerative colitis in rats
نویسندگان
1 Endocrinology and Metabolism Research Center, Institute of Basic and clinical physiology, Kerman University of Medical Sciences, Kerman, Iran.
2 4. Payame Noor University, Isfahan, Iran
3 School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
4 1. Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
5 natural products and medicinal plants research center, north khorasan university of medical sciences, bojnurd, Iran
6 Department of Pathology, University of Medical Sciences, Kerman, Iran
doi
10.22038/ajp.2018.11276چکیده
Objective: In this study, we elucidated the ameliorative effect of aqueous extract of leaves of Mumiju against acetic acid-induced experimental colitis in male rats. Materials and Methods: The animals were randomly divided into four groups (n=7) including I: control group, II: vehicle group (injected with 2 ml acetic acid (4%) intra rectally), III and IV: treatment groups which received Mumiju (250 mg/kg) orally or intraperitoneally for 4 consecutive days after ulcer induction. Ulcer index, severity of inflammation, colonic levels of superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA), and histological changes were recorded after the treatment regimen of 4 days. Results: The ulcer index, severity of inflammation and colonic MDA levels were increased following intrarectal instillation of acetic acid. Also, acetic acid significantly decreased the SOD and GSH levels. Treatment with Mumiju for 4 days exhibited significantly lowered oxidative stress, while elevated of SOD and GSH levels. Regenerative-healing patterns also was seen by histopathological findings after treatment with Mumiju. Conclusion: The present investigation demonstrates that Mumiju could be regarded as a herb with potent therapeutic value in the amelioration of experimental colitis in laboratory animals by modulation of oxidant- antioxidant system.
