Hepatoprotective activity of Mammea africana ethanol stem bark extract
نویسندگان
1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
2 Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
3 Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
doi
10.22038/ajp.2016.5445چکیده
Mammea africana Sabine (Guttiferae) stembark, a common plant, traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol- induced liver injury in rats. The hepatoprotective effect of the stembark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters: total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), and alkaline phosphatase activities (ALP), antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and histopathological study of the liver. The administration of the stembark extract caused significant (p
