فهرست نشریات علمی دسترسی آزاد ایران

Background: Magnetic nanoparticles have been widely applied in recent years for biomedical applications. Signal intensity (SI) of magnetic resonance (MR) images depends on the concentration of nanoparticles. It is important to find the minimum concentration of iron oxide nanoparticles that produces maximum SI and determines the minimum injection dose for clinical studies. Objectives: This study was performed to determine the relationship between the iron oxide nanoparticle concentration and SI using inversion recovery (IR) sequence in T 1 -weighted MR images. Results: The results indicate that SI depended on the concentration of nanoparticles and TI. In addition, SI increased by increasing the TIs ranging from 200 to 400 ms for all studied concentrations. The linear relationship between the nanoparticle concentrations and SI that gave a square correlation coefficient (R 2 ) equal to 0.99 was seen up to 76.83 µmol Fe/L in 400 ms for long TI and 239.16 µmol Fe/L in 200 ms for short TI. Conclusions: TI is an important parameter to consider in the relationship between SI and nanoparticle concentrations. An increase in TI leads to a decrease in the range of linearity.