فهرست نشریات علمی دسترسی آزاد ایران

Background: Proton magnetic resonance spectroscopy imaging (1H-MRSI) has recently attracted attention in musculoskeletal applications in general, and in osteosarcoma in particular. Acquired spectra in the MRSI procedure are usually corrupted due to low signal-to-noise ratio (SNR), as well as baseline and residual water contaminations, leading to quantification errors and; therefore, misinterpretation of the ratios calculated by the clinical scanners software. Objectives: The aim of this study is accurate quantification of Choline-to-Creatine (Cho/Cr) ratio elevating in osteosarcoma. Results: The average values of Cho/Cr for 10 patients and 10 volunteers were 0.448 + 0.055 and 0.324 + 0.030, respectively, and the meaningful change of 35% (P < 0.0001) between the two groups. Reliability of the quantitative results was estimated by employing CRB which was about 93.6% among the 10 volunteers. Conclusions: In this study, we managed to observe meaningful changes in the Cho/Cr ratio in osteosarcoma lesions versus the control group employing 1H-MRSI. The best database for subtract-QUEST-MRSI was optimized in osteosarcoma. Reliability of the quantitative results was about 93.6% among the 10 volunteers.