فهرست نشریات علمی دسترسی آزاد ایران

Objectives: The goal of our study was to assess diffusion-weighted (DW) imaging and proton magnetic resonance (MR) spectroscopy findings in osteosarcoma versus normal muscle at 3 Tesla (3 T) MR system. Results: The minimum apparent diffusion coefficient (ADC) value of osteosarcoma (0.88 ± 0.28) in this study confirms the significant restriction of this tumor against the dark background of normal muscle in high b-value images. Fourteen (82%) of the available 17 patients had ADC values ≤ 1 × 10 -3 mm 2 /s. The maximum choline/creatine (Cho/Cr) ratio of osteosarcoma (1.94 ± 1.12) was statistically higher than the normal muscle (1.34 ± 0.11). Receiver operating curve (ROC) analysis (the area under the curve = 0.7) indicated a maximum Cho/Cr ratio of 1.37 as the cut point between the normal muscle and osteosarcoma, with a sensitivity, specificity and accuracy of 58.8%, 83.3%, and 69%, respectively. All patients with Cho/Cr ratios more than the cut point had ADC values ≤ 1 × 10 -3 mm 2 /s and all patients with ADC values higher than 1 × 10 -3 mm 2 /s had Cho/Cr ratios ≤ 1.37. Conclusion: It was concluded that DW imaging and proton MR spectroscopy are two effective noninvasive techniques in the evaluation of osteosarcoma.