فهرست نشریات علمی دسترسی آزاد ایران

Background: The effect of various environmental and intrinsic stimulators on the development of brown adipose tissue (BAT) has been widely investigated by PET-based researches. However, evidence regarding the influencing factors on the level of BAT metabolic activity is scarce. Objectives: The aim of the present study was to evaluate the frequency of cancer-related characteristics in addition to anthropometrics and demographics in BAT-bearing cancer patients at 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scan and any correlation between the level of BAT metabolic activity and the influencing factors. Results: Sixty-two F-18 FDG PET/CT studies demonstrated BAT related 18-F FDG uptake (1.6%, 32% male, 68% female, P = 0.007, mean age 22.9). Lymphoma (43.5%) and treatment response evaluation (54.54%) were the most frequent type of cancer and reason for referral, respectively. Most patients were in status partial or complete metabolic response to treatment. Fifty-four point eight percent of patients had at least one metabolically active cancer-related lesion. BAT detection rate was higher in females in all adult age groups, younger age (< 40 years old), body mass index (BMI) and body fat (BF) below the obesity cut off and autumn/winter seasons. The dominant distribution pattern of BAT depots was neck, mediastinum, paravertebral (33.87%) with the highest level of metabolic activity in the axillary region. SUVmax demonstrated a weak inverse correlation with age (0.015), evidence of active malignant disease and no recent treatment. Linear regression test demonstrated that age (P = 0.021) and recent treatment (P = 0.033) have independent correlation with BAT SUVmax. Conclusion: The present study provided evidence for age and chemotherapeutic agents on the level of BAT metabolism. In addition, there is a suggestion for different pathways involved in BAT development and regulation of the level of metabolic activity.