فهرست نشریات علمی دسترسی آزاد ایران

Background: Traumatic brain injury (TBI) can result from blunt trauma or acceleration/deceleration force and is considered to be one of the most important public health problems. Many patients of TBI lose professional competence and independence. They may eventually suffer serious sequelae, such as cognitive impairment, memory loss, and long-term headache. In craniocerebral trauma patients, mild traumatic brain injury accounts for 70% - 80% of the cases. Early diagnosis and intervention can decrease the post-concussional sequelae for mild TBI (mTBI). Objectives: To investigate the value of diffusion kurtosis imaging (DKI) in mild traumatic brain injury (mTBI) patients. Results: FA and MK values were significantly different in all of the white matter and grey matter, while MD values among the various ROIs were insignificantly different in the healthy control group. In mTBI patients, the FA values of genu of corpus callosum, splenium of corpus callosum, and external capsule were decreased. Whereas, MD value of genu of corpus callosum in trauma group was increased. Except for the head of the caudate nucleus and posterior limb of the internal capsule, the MK values of the rest of the ROIs in the trauma group decreased significantly. Moreover, compared with the contra-lateral, there were more significant contusion lesions of FA and MK reductions than increased MD values. FA and MD values of peri-contusion had no significant difference compared with the contra-lateral while MK values decreased significantly. Conclusion: Compared with conventional MRI sequences, DKI can detect micro white matter injury, and MK parameter is more sensitive than FA and MD. In addition, DKI can find these changes not only in the white matter but also in deep gray matter nucleus, making it a promising imaging tool to assist the detection of mild traumatic brain injury.