فهرست نشریات علمی دسترسی آزاد ایران

Background: Scar tissue formation is a common phenomenon in myocardial infarctions. Contrast-enhanced cardiac magnetic resonance imaging is the modality of choice to evaluate the location and size of the scar tissue. Nevertheless, in patients with severe kidney impairment, administration of gadolinium is contraindicated. Objectives: So the aim of this study was to substitute a safe way for myocardial infarction assessments in patients with a history of renal function impairment. We assessed the T2* quantitative value changes in myocardial infarction-related scar tissue and compared them with normal/remote myocardial tissue T2* values to evaluate its application in non-contrast cardiac magnetic resonance imaging viability assessments. Results: T2* (mean ± SD) values of the normal/remote, peri-infarction, and infarcted myocardial tissues were calculated as 29.42 ± 4.50, 30.71 ± 4.86, and 35.46 ± 3.61, respectively. There was a significant alteration in the post-infarction scar tissue’s myocardial T2* values by comparison with the normal/remote myocardium (P < 0.001). No significant differences were noticed between the normal/remote and peri-infarction regions’ T2* relaxation times (P > 0.05). Area under the curve was 81% for patients evaluated for scars. Cutoff value of 31.70 yielded 92% sensitivity and 72% specificity. Conclusion: T2* relaxation time can provide useful and sensitive information on scar tissue formation location, and can offer a greater sensitivity into the non-contrast CMR imaging viability assessments besides other relaxation phenomena, especially the longitudinal relaxation time.