فهرست نشریات علمی دسترسی آزاد ایران

Background: There are many more trials for low-dose chest computed tomography (LDCT) screening than for chest radiography, as a recent study shows that low-dose chest CT screening for smokers may reduce lung cancer mortality. Objectives: To assess the differences of low-dose CT imaging features between smokers and non-smokers. Results: Among 304 patients (130 in the non-smoker group and 174 in the smoker group), the number and diameter of nodules, pleural lesions, lymphadenopathy, and bronchiectasis were not significantly different between the smoker and non-smoker groups. Emphysema was detected in 11 (8.5%) patients in the non- smoker group and 75 (43.1%) in the smoker group. Coronary artery calcifications developed in 22 patients (16.9%) in the non-smoker group and 60 patients (34.5%) in the smoker group. Respiratory bronchiolitis developed in two patients (1.5%) in the non-smoker group and 13 patients (7.5%) in the smoker group. With an increase in the smoking period, emphysema and coronary artery calcifications significantly increased (P = 0.002 and P = 0.007, respectively). Conclusion: In the LDCT findings, emphysema, coronary artery calcifications, and respiratory bronchiolitis were significantly different between smokers and non-smokers. In multivariate analysis, emphysema was only significantly different between smokers and non-smokers. With an increase in the smoking period, the occurrence of emphysema and coronary artery calcifications increased as well at univariate and multivariate analysis.