فهرست نشریات علمی دسترسی آزاد ایران

Background: Computed tomography (CT) lung perfusion scan could be used to evaluate regional, morphologic, and functional changes in chronic obstructive pulmonary disease (COPD) noninvasively. However, the dual hemodynamic changes in severe COPD patients have not been studied quantitatively using CT lung perfusion scan. Objectives: To determine the dual hemodynamic changes quantitatively in patients with severe COPD by using low-dose CT lung perfusion scan. Results: The PAF and PI values in the COPD group were significantly lower than that in the control group (P < 0.001, P < 0.001), while the BAF value was significantly higher (P < 0.001). The TTP of impaired lung parenchyma was significantly prolonged compared to the normal lung parenchyma (P < 0.001). Conclusion: Patients with severe COPD have distinct changes in pulmonary dual hemodynamics. Low-dose lung perfusion scan using a 320-detector row dynamic volumetric CT could be used to evaluate the pulmonary dual hemodynamics.