فهرست نشریات علمی دسترسی آزاد ایران

Background: High field strength magnets have the potential to provide good quality diffusion weighted imaging (DWI) sequence images and apparent diffusion coefficient (ADC) maps can give important data for differential diagnosis of thyroid nodules. Objectives: To determine the sensitivity and specificity of ADC values of malignant and benign thyroid nodules at 3 Tesla (T) magnetic resonance imaging (MRI) and to correlate imaging findings with histopathologic results. Results: Thirteen malignant and 63 benign nodules were analysed. The ADC MEAN values of malignant nodules were significantly lower than benign nodules in each b value (P < 0.0001). Nodular ADC MEAN /thyroid parenchymal ADC MEAN ratio was significantly lower in the malignant group at b:500 and b:1000 (P < 0.0001). Considering the selected cut off values (0.98 for b:500 and 0.95 for b:1000) this ratio showed the best performance in differentiation of malignant and benign nodules with a sensitivity of 100% and specificity of 92% - 100%. Conclusion: DWI with quantitative ADC measurements is useful in the differentiation of benign and malignant thyroid nodules. The nodule ADC MEAN /thyroid parenchyma ADC MEAN ratio can be used as an adjunctive parameter in differentiation.