فهرست نشریات علمی دسترسی آزاد ایران

Background: Hypoxia is an important cause of recurrence and metastasis of malignant tumors. Noninvasive detection of the extent of hypoxic areas of tumors is essential for delineation of radiotherapy target areas and dose. Objectives: To investigate the feasibility of 99 Tc m -2-(2-methyl-5-nitro-1H-imidazol-1-yl) ethyl dihydrogen phosphate ( 99 Tc m -MNLS) hypoxic imaging to monitor the tumor hypoxic state in tumor-bearing mice after radiotherapy. Results: T/NT ratio and the expression of HIF-1α in A 24 h group were not significantly different from those in A 24 h before and control groups, but lower than those in the A immediately group and higher than those in the A 48 h group. T/NT ratio and the expression of HIF-1α in the A 24 h before group had no significant difference compared with those in its control group, while those in the A immediatel y group were remarkably higher than those in its control group. On the other hand, those in A 48 h group were lower than those in its control group. There was a positive correlation between T/NT ratio and HIF-1α expression in radiotherapy group and control group at different time points. Conclusion: 99 Tc m -MNLS tumor hypoxic imaging can evaluate the tumor hypoxic status of tumor-bearing mice after radiotherapy.