فهرست نشریات علمی دسترسی آزاد ایران

Background: Intrauterine growth restriction (IUGR) is a major factor in long-term perinatal morbidity and is associated with abnormal fetal brain development; however, its pattern of brain involvement remains unknown. Objectives: This study aimed to investigate the effect of IUGR on the brain parenchyma. Results: In the IUGR group, the cortical thickness in the insula and temporal lobe was significantly thinner than the control group (0.034 vs. 0.043 and 0.036 vs. 0.047, respectively; P < 0.05); these fetuses also showed significantly reduced WBA (P = 0.028). The corrected brain areas were not significantly different between the groups, except for the corrected areas of the cerebellum and the hippocampus, which increased in the IUGR group as compared to the control group (0.147 vs. 0.130 and 0.017 vs. 0.0125, respectively; P < 0.05). Conclusion: In the IUGR fetuses, significantly thinner insular cortex and temporal lobe cortex and smaller WBA were found compared to the control group. Among different brain regions, the cerebellum and the hippocampus were less affected by growth restriction in the antenatal period.