فهرست نشریات علمی دسترسی آزاد ایران

Background: The association between chronic nephrolithiasis and several systemic conditions has been established in previous studies. Patients with recurrent urinary stones generally experience more urinary calcium loss, resulting in a lower bone mineral density (BMD). Dual-energy X-ray absorptiometry (DEXA) is the standard imaging method for diagnosing a low BMD. However, imaging imposes significant cost and radiation burden on patients. Objectives: We aimed to assess the relationship between 24-hour urinalysis biometrics and bone mineral content, retrieved from non-contrast computed tomography (CT) imaging, which is routinely preformed for urinary stone patients as a primary evaluation. Results: The present results showed a significant association between the stone size and BMD (P < 0.05). Moreover, patients with a low BMD had a higher urinary calcium excretion in the 24-hour urinalysis (P < 0.05). Evaluation of urine chemical composition and stone size demonstrated a significant association between hypercalciuria and urinary stone volume (P < 0.05). Conclusion: A low BMD detected by CT imaging in patients with urinary stones is associated with abnormal 24-hour urinalysis biometrics and larger stones; therefore, it should be properly assessed.