فهرست نشریات علمی دسترسی آزاد ایران

Background: Hepatocellular carcinoma (HCC) is characterized by high morbidity and mortality rates around the world, ranking the sixth most common malignant tumor and the second cause of cancer-related mortality. Most patients are diagnosed in the advanced stage, and therefore, there are limited therapeutic options. Transarterial chemoembolization (TACE), anti-angiogenic therapy, and immune checkpoint inhibitors (ICIs) are the research hotspots in HCC treatment. Objectives: This study aimed to explore the treatment efficacy and safety of TACE for refractory HCC patients after anti-angiogenic therapy combined with ICIs. Results: A total of 34 patients were evaluated in this study, with a median PFS of five months (95% CI: 3.7 months, 6.3 months). The univariate analysis suggested that the level of aspartate aminotransferase was significantly associated with PFS (P < 0.05). The objective response rates within three and six months were 26.4% and 14.6%, and the disease control rates were 58.8% and 55.9%, respectively. During the follow-up, one or more types of adverse events were reported in 10 (58.8%) patients after treatment with atezolizumab and bevacizumab, while severe adverse events beyond grade III did not occur in any of the patients. Conclusion: The TACE may improve the survival of HCC patients, whose disease progresses after anti-angiogenic therapy combined with ICIs. However, the lack of a control group is one of the limitations of this study.