فهرست نشریات علمی دسترسی آزاد ایران

Background: Osteoarthritis (OA) is the most common musculoskeletal disorder causing disability and loss of function, particularly in the elderly. Preclinical and in-vitro studies for mitigation of OA symptoms suggest the protective role of pomegranate juice against OA; this effect is mainly attributed to its polyphenol content. Objectives: This study aimed to evaluate the effects of pomegranate juice on physical function of and proinflammatory cytokines in patients with knee OA. Results: Significant decreases in difficulty of physical function were observed after intervention in the pomegranate juice group (P = 0.01). There was no significant difference in serum levels of TNF-α and IL-1β before and after the intervention in the two study groups. Conclusions: Taken together, pomegranate juice did not affect serum cytokines levels in patients with OA. Its role in improving physical function in these patients most likely involves other mechanisms.