فهرست نشریات علمی دسترسی آزاد ایران

Background: Inhibiting the effect of aspirin on prostaglandin results in corpus luteum maintenance in pregnant mice. Uterine natural killer (uNK) cells activate between 5 - 7 days of pregnancy. uNK cell differentiation is indirectly regulated by ovarian hormones. Immune cells have important roles in the endometrium at early pregnancy stages. Although low-dose aspirin is effective on ovarian hormones, the effect of low-dose aspirin on the uNK cell population at early pregnancy stages is unknown. Objectives: The aim of this study was to assess the effect of low-dose aspirin on uNK cells at day seven of pregnancy. Results: The ovarian hormones level showed a significant difference between the experimental and control groups (P < 0.05). Furthermore, the uNK cell population showed a significant difference between the two groups (P < 0.05). Conclusions: Increased ovarian hormones due to low-dose aspirin administration resulted in decline in the uNK cells number, which may be effective in successful pregnancy.