فهرست نشریات علمی دسترسی آزاد ایران

Introduction : Eosinophils are inflammatory cells that perform diverse functions and play roles in both homeostasis and disease in various tissues. Evidence indicates that many patients with chronic respiratory conditions, including asthma and COPD, exhibit persistent eosinophilic airway inflammation. This study aimed to evaluate the prevalence of blood eosinophilia in patients with obstructive patterns on spirometry. Materials & Methods : This cross-sectional study was conducted on patients attending the Hazrat Rasoul Akram Hospital, affiliated with Iran University of Medical Sciences. Patients who underwent spirometry and had peripheral blood tests were included in the study. Information regarding age, gender, body mass index, underlying diseases, smoking habits, medication use, spirometry results, and complete blood count (CBC) was collected and analyzed statistically. Results : A total of 103 participants were selected based on the inclusion criteria and participated in the study. In the current study, 8 patients (7.8%) were eosinophilic-positive and 95 patients (92.2%) were eosinophilic-negative. The mean FEV1 in the eosinophilic-negative group was 63.25% (with a standard deviation of 20.585), while in the eosinophilic-positive group it was 60.00% (with a standard deviation of 14.203). Statistical tests confirmed no significant difference between the two groups, suggesting that reduced FEV1 was not associated with blood eosinophilia in this population. Additionally, the mean FEV1/FVC ratio in the eosinophilic-negative group was 80.72% (with a standard deviation of 17.10), and in the eosinophilic-positive group it was 77.33% (with a standard deviation of 15.62), which also showed no statistically significant difference. Conclusion : This study found no significant association between blood eosinophilia and demographic or pulmonary function variables in patients with obstructive patterns on spirometry. Future studies with more precise designs and larger sample sizes may clarify the role of eosinophilia in prognosis and treatment response.