فهرست نشریات علمی دسترسی آزاد ایران

Introduction : Despite traumatic brain injury (TBI) being a leading cause of global morbidity and mortality, it lacks easy-to-access or portable, reliable biomarkers for early diagnosis. This study was designed to evaluate serum Opalin, a CNS-specific protein, in drug-naïve TBI patients. Materials & Methods : Conducted as a prospective case-control study at a tertiary care setting, 60 drug-naïve TBI patients and 60 healthy controls (HC) were evaluated for serum Opalin levels. Results : TBI patients showed significant alterations in serum Opalin levels. Opalin demonstrated high diagnostic accuracy (AUC: 0.943) with 86.67% sensitivity and 95% specificity at a cut-off of 321.7 pg/mL. Strong correlations were found between Opalin levels and TBI severity (using CT scan and Glasgow coma scale score). Conclusion : This research underscores the potential application of serum Opalin to augment current evaluation methods like CT scan and Glasgow coma scale evaluations.