فهرست نشریات علمی دسترسی آزاد ایران

Introduction : The present study aimed at identifying the risk factors associated with overall survival (OS) of breast cancer (BC) patients using multivariate Cox extended models. Materials & Methods : This retrospective cohort study was conducted on 348 women with BC who were followed up for 10 years. Kaplan-Meier (KM) and log-rank statistics, Cox proportional hazard (PH), and multivariate Cox models were used to analyze the data. STATA V.17 and SPSS V.27 were used for data analysis. Results : The median age of the patients was 55 years, and the median survival time was 29 months. Five- and 10-year OS were estimated at 93.4% and 88.4%, respectively. The results of multivariate analysis using the Cox model showed that lymph node (LN+) (hazard ratio (HR) = 2.86, P = 0.002), tumor size (HR = 1.99, P = 0.001), and progesterone receptor (PR-) (HR = 4.5, P = 0.002) increase death hazard significantly. Conclusion : Prognostic factors indicated that women with lymph node involvement (LN+), positivity of human epidermal growth factor receptor 2 (HER2+), negativity of estrogen receptor (ER-), negative expression of progesterone receptor (PR-), advanced disease grade, and large tumor sizes were more likely to have a high hazard of death than other women.