فهرست نشریات علمی دسترسی آزاد ایران

Introduction : Glycated hemoglobin (HbA 1 c) is widely used to assess long-term glycemic control in diabetic patients. However, non-glycemic factors such as iron deficiency anemia (IDA) may alter HbA 1 c levels, potentially affecting its accuracy. This study aimed to evaluate the effect of IDA on HbA 1 c levels in diabetic patients with controlled fasting plasma glucose. Materials & Methods : An analytical cross-sectional study was conducted on 80 diabetic patients aged 18–60 years, divided equally into IDA and non-IDA groups. IDA diagnosis was based on hemoglobin levels, red blood cell indices, serum ferritin, serum iron, and total iron-binding capacity (TIBC). HbA 1 c was measured using high-performance liquid chromatography; while fasting plasma glucose was determined by the glucose oxidase-peroxidase method. Results : Mean HbA 1 c levels were 6.1 ± 0.59% in the IDA group and 6.2 ± 0.73% in the non-IDA group, with no statistically significant difference (p = 0.6143). Age and gender showed more influence on HbA 1 c values than IDA status. No significant correlation was found between HbA 1 c and hematological or iron parameters within the IDA group. Conclusion : Iron deficiency anemia does not significantly affect HbA 1 c levels in diabetic patients with well-controlled fasting glucose. Therefore, HbA 1 c remains a reliable marker for glycemic control in these patients. Clinicians should still interpret HbA 1 c cautiously in anemic individuals and consider additional assessments if necessary.