Effect of PTZ-induced acute seizures on anxiety-like behaviors in open field test in male mice
نویسندگان
1 department of Physiology, faculty of medical sciences, Zanjan university of Medical Sciences, Zanjan, Iran
2 department of Physiology, faculty of medical sciences, Zanjan university of Medical Sciences, Zanjan, Iran
3 department of Physiology, faculty of medical sciences, Zanjan university of Medical Sciences, Zanjan, Iran
4 department of Physiology, faculty of medical sciences, Zanjan university of Medical Sciences, Zanjan, Iran
doi
10.48311/mjms.2026.118501.82613چکیده
Background: Seizures induce transient changes in behavior, including changes in anxiety-related exploration. In the present study the effect of acute pentylenetetrazol (PTZ)-induced seizures on activity and exploration in open-field test was investigated.Methods: Eight adult male C57BL/6 mice (weighing 20-25 g) were subjected to the open-field test before and 24 hours after intraperitoneal administration of PTZ (60 mg/kg) to induce an acute seizure model. Behavioral parameters, including time spent in the center zone (center time), number of crossings, and distance traveled in the center zone, were evaluated.Results: PTZ injection significantly reduced center time (P < 0.05) and had a large effect on reducing the number of crossings (d = 1.16) and center distance moved (d = 0.8) parameters. These data suggested a meaningful alterations in exploratory behavior following PTZ injection.Conclusion: These findings indicated that acute PTZ-induced seizures are associated with changes in anxiety-like behavior, particularly reflected by reduced exploration of the central area of the open-field arena.
